Open-air heroin use, mentally disturbed homeless people, human waste and troubling spasms of violence have turned a stretch of the East Village into a “s–thole,” locals say.

The area along East 14th Street, between First Avenue and Avenue A, was a dangerous eyesore even before the broad-daylight stabbing on Sunday that left one person dead and two others wounded, according to residents.

“It’s a s–thole. It’s horrid,” Barbara N., who has lived in the neighborhood since the 1980s, told The Post on Monday.

“It has gotten so bad.”

Kirsten Theodos, a former East Village resident, told The Post that the area started to change about 2019, when she noticed the local CVS started locking up deodorant and ice cream.

Homeless people started to camp near her building, “heroin needles” proliferated and locals began calling one sidewalk the “Thieves’ Corner,” Theodos said.

“I moved out because the conditions on 14th and First are unbearable,” the mother of two said.

Powers called the situation “out of control,” while Rivera blamed underinvestment in mental health.

Even disgraced Democratic pol and selfie enthusiast Anthony Weiner whipped out some unsolicited advice.

He tweeted that the NYPD should move cops posted in a vehicle near Target to a foot patrol.

“I refer you to the beat cop of yore,” he wrote.

Powers called the situation “out of control,” while Rivera blamed underinvestment in mental health.

Even disgraced Democratic pol and selfie enthusiast Anthony Weiner whipped out some unsolicited advice.

He tweeted that the NYPD should move cops posted in a vehicle near Target to a foot patrol.

“I refer you to the beat cop of yore,” he wrote.